| Citation: | HUANG Tianhui, GUO Xiaolin. Chitosan/polylactic acid composites prepared by emulsion freeze-drying technique[J]. Journal of Beijing University of Aeronautics and Astronautics, 2017, 43(1): 1-6. doi: 10.13700/j.bh.1001-5965.2016.0051(in Chinese)
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The combination between hydrophilic extracellular matrix polysaccharides and hydrophobic aliphatic polyesters is a challenge in the biomaterial field. Here we investigated the formation of chitosan/polylactic acid (CS/PLA) composites using a novel emulsion freeze-drying technique, in which CS solution, CH3 in PLA solution and Tween80 were used as water phase, oil phase, and surfactant, respectively. FTIR revealed that there are strong hydrogen bond interactions between CS and PLA. The composites showed well interconnected pore structure and homogenous distribution of CS and PLA as the PLA volume fraction was not higher than 50% by SEM observation. The porosity of the CS/PLA composites was in the range of 85%-90% and showed slight decrease with increasing PLA dose. When the PLA contents increased from volume fraction of 25% to 75%, the compressive strength of the composites increased from 0.20 MPa to 0.33 MPa, while the compressive modulus increased from 2.84 MPa to 4.83 MPa. The successful CS/PLA amphiphilic composites offer a novel strategy for biomaterial design and configuration.
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